On December 21, 1886, her parents' 29th wedding anniversary, Juliette married William Mackay Low, a wealthy Englishman, at Christ Church in Savannah, Georgia. Although the couple moved to England, Juliette continued her travels and divided her time between the British Isles and America.

Before her marriage, Juliette had suffered from chronic ear infections. She had lost most of her hearing in one ear because of improper treatment. At her wedding, when she was 26, she lost hearing in her other ear after a grain of good-luck rice thrown at the event lodged in her ear. When trying to remove the rice, the doctor punctured the eardrum and damaged the nerve-endings resulting in a total loss of hearing in that ear.

During the Spanish-American War, Juliette came back to America to aid in the war effort. She helped her mother organize a convalescent hospital for wounded soldiers returning from Cuba. Her father, who had been a captain in the Confederate army, was commissioned as a general in the U.S. Army and served on the Puerto Rican Peace Commission. At the end of the war, Juliette returned to England to a disintegrating marriage. The Lows were separated at the time of her husband's death in 1905.